Istituto Ortopedico Rizzoli di Bologna

Fulvia Taddei

coordinator

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Enrico Schileo

expert

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Giordano Valente

lead expert

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Nicola Vanella

developer

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Gianluigi Crimi

lead developer

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Enrico Lenzi

Pre-clinical studies: in vitro

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Yasmin Saleh

Research scholar

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Cristina Manferdini

Biomedical Laboratory Technician

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Paolo Dolzani

Biologist

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Matilde Tschon

Biologist

Matilde Tschon, Ph.D. (gender: female, date of birth: 25/08/1974) is a permanent biologist at the Laboratory of Preclinical and Surgical Studies of IOR. She is referent of Tissue Engineering Sector of the lab. She studied at the University of Bologna, faculty of Biological Sciences and received her degree in 2002; then she obtained a PhD degree in Biomaterials at the University of Pisa. Her research interests focus primarily on the study of biocompatibility of biomaterials/scaffold/medical device for the repair/regeneration of musculoskeletal tissues (cartilage, bone, meniscus, tendon and ligament), studies on regenerative medicine and tissue engineering approaches, design, execution and data analysis of in vitro and in vivo preclinical research, in vitro cell cultures and alternative methods, histology and histomorphometry. She is author of 49 scientific publications with a H-index of 21 (Source: Scopus).

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Elena Gabusi

Biologist

Elena Gabusi, Ph.D., (gender: female, date of birth: 04/12/1969) will contribute to molecular profile analysis of the nanocomposite construct. She has a Degree in Biological Science at University of Bologna, Italy and she has a Specialist Qualification in Toxicology, at University of Bologna. She is a biology research manager in the Laboratory of Immunorheumatology and Tissue regeneration and has good skills in the application of tools for word processing, database management, graphic systems and statistical analysis. She has clinical and scientific interests in: bone and cartilage biology in normal and pathologic patients (osteoarthritis, rheumatoid arthritis and osteoporosis), tissue engineering and regenerative medicine. She has a H-index of 18 (Source: Scopus).

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Milena Fini

Director

Milena Fini, M.D. (gender: female, date of birth: 22/10/1962). Degree in Medicine and Surgery (1989), Specialization in Emergency in Surgery with honours (1994) and Specialization in Orthopaedic and Traumatology with honours (2003) – Faculty of Medicine, University of Bologna; II Level Master in “Clinical Governance of Research in healthcare” – University of Modena and Reggio Emilia (2011). She is director of the Laboratory of Preclinical and Surgical Studies (from 2010) and is the Person in Charge of Research and Organization of the Laboratory of Biocompatibility, Technological Innovations and Advanced Therapies – Rizzoli RIT Department (from 2009); Responsible of Animal Welfare and related equipment following Directive 2010/63/EU on the protection of animals used for scientific purposes; Coordinator of the IOR Translational Research Line “Musculoskeletal Regenerative Medicine” – IOR (from 2013). She is involved in preclinical and clinical research projects on regenerative medicine of bone and cartilage, biomaterials, mesenchymal stem cells for the treatment of musculoskeletal diseases (funded from the Italian Ministry of Health, Ministry of Education, Universities and Research, Enterprises, Bank foundations, Emilia Romagna Region). She is editorial Board member of BioMed Res Int; advisory Board member of JAB-FM; Executive Member of SIB, ISMULT, Indo- Italian Forum of Biomaterials and Tissue Engineering; National Delegate Cost Action-MB1301; Expert of Reference Center for Alternative Methods, Welfare and Care of Laboratory Animals, IZSLER. Her main scientific interests include biomaterials, biocompatibility, scaffolds, tissue engineering and regenerative medicine of the musculoskeletal tissues, in vitro advanced models and in vivo preclinical research, osteointegration, osteoporosis, osteoarthritis, tendinopathies, osteolysis, fractures and bone losses, bone metastases, osteomyelitis. She is author of more than 485 publications, with a H-Index of 55 (source: Scopus).

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Stefano Zaffagnini

Director

Stefano Zaffagnini, M.D. (gender: male, date of birth: 20/09/1962), MD Degree with Honors (1987) at University of Bologna, Specialization in Orthopaedics and Traumatology with Honors. From 2008, he is coordinator of the Sports Traumatology Excellent Centre of Istituto Ortopedico Rizzoli of Bologna Italy. From 01/04/2016 he is full Professor in Orthopaedic s and Traumatology at Faculty of Medicine. From March 2017 he is Director of the II Clinic Orthopaedic and Traumatology of the Istituto Ortopedico Rizzoli. He takes part in several research projects promoted by IOR and the Italian Health Ministry and European Community. He serves as reviewer for several international journals. From August 2009 he is a member of the “Anterior Cruciate Ligament Study Group”. He is designated as Scientific Chairman of the 10th I.S.A.K.O.S Congress and as Scientific Co- Chairman of the 11th I.S.A.K.O.S Congress. He is member of ESSKA Sport Committee 2014 – 2016. He is author of more than 263 publications on Pub Med, with a H-index of 37(source: Scopus).

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Alessandro Russo

MD

Alessandro Russo, M.D. (gender: male, date of birth: 05/03/1975) is assistant orthopedic surgeon in the II Orthopedic and Traumatologic Clinic at Rizzoli Orthopedic Institute, Bologna – Italy since March 2006. He works as researcher in the Nanobiotechnology Laboratory of Codivilla-Putti Reserch Institute (Istituto Ortopedico Rizzoli – Bologna, Italy) in the area of osteochondral/ bone regeneration and nanostructured materials for orthopedic applications. Dr. Alessandro Russo was actively involved in the European Project MAGISTER (NMP3-LA-2008-214685). The MAGISTER project has successfully promoted an innovative approach introducing for the first time the notion of magnetic scaffolds (MagS) for bone and osteochondral tissue engineering and regeneration. He won the 2010 Young Searching Ministerial Project with the Project: “Nanostructured Coatings Enhancing Material Performances in Joint Arthroplasty” GR- 2010- 2312686. Dr. Alessandro Russo took part in the “Start Cup Competition – University of Bologna” and won the “Special Price Nanotech 2008” with the PRO ART project (hard coatings for Articular prostheses). He participated in the final phase of the “National Innovation Price 2008” with the PRO ART project (Hard coatings for Articular Prostheses Politecnico di Milano 27-28 November 2008). He is author of 70 papers on Pub Med, with a H-Index of 18 (source: Scopus).

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Dr. Pier Maria Fornasari

Coordinatore del WP

Direttore del Servizio di Immunoematologia e Medicina Trasfusionale e della Banca del Tessuto Muscoloscheletrico (BTM)

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Prof. Nicola Baldini

Unit Leader

Professore associato e Responsabile del Laboratorio di Fisiopatologia ortopedica e medicina rigenerativa. Coordinatore delle attività di ricerca incentrate sulla caratterizzazione e valutazione in vitro delle mesenchimali e sull’analisi istologica dei campioni ossei.

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Prof. Davide Maria Donati

Unit Leader

Professore associato e Direttore f.f. della Clinica Ortopedica e Traumatologica III a prevalente indirizzo Oncologico e Responsabile Tecnico-scientifico dell’Unità di Patologia Ortopedica e Rigenerazione Tissutale Osteoarticolare. Responsabile della selezione e arruolamento dei pazienti, degli interventi chirurgici e delle valutazioni al follow-up.

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Dr. Dante Dallari

Coordinatore di WP

Responsabile della Chirurgia Ortopedica Conservativa e Tecniche Innovative. Responsabile della selezione e arruolamento dei pazienti, degli interventi chirurgici e delle valutazioni al follow-up.

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Dr. Ugo Albisinni

Unit Leader

Direttore della Radiologia diagnostica ed interventistica. Responsabile delle valutazioni diagnostiche per immagini previste all’interno dello studio clinico.

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Dr.ssa Brunella Grigolo

Unit Leader

Ricercatrice del Laboratorio di Immunoreumatologia e Rigenerazione Tissutale e Responsabile Organizzativo delLaboratorio RAMSES. Responsabile degli studi preclinici in vitro focalizzati sulla caratterizzazione del concentrato midollaree sulla valutazione dei biomarkers ossei nel trattamento delle lesioni osteocondrali.

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Prof. Sandro Giannini

Coordinatore WP

Direttore della Clinica Ortopedica e Traumatologica I.Responsabile dell’ arruolamento dei pazienti loro trattamento e valutazione al follow-up

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Dr.ssa Gina Lisignoli

Biologist

Gina Lisignoli, Ph.D., (gender: female, date of birth: 02/03/1964) (IOR Scientific Responsible) is senior researcher at IOR and head of the Research Unit: “Physiopathology and bone tissue regeneration” in the Laboratory of Immunoreumatology and Tissue Regeneration. She was tutor of 18 PhD students and supervised their theses on the two main topics of the Lab, namely regenerative medicine and immune-rheumatology. She carried out innovative research in the field of osteoarthritis treatment and regeneration collaborating with experts in other disciplines (engineers, physicists, biotechnologists, etc.). She is co-author of more than 100 scientific publications (95 on ISI journals) and 9 book chapters. She is reviewer of more than 30 scientific international journals and of 10 international grants. She is also inventor of 2 patents. She has a H-index of 30 and a total of 2496 citations according to the Scopus source. Since 2002 she has worked with different national and international companies that granted scientific projects for a total amount of ~400 k€. She has established national and international collaborations thanks to the following funded projects:

Italian Ministry of Health project: “Biological and genetic markers of osteoarthritis severity”. Started in May 2001. Duration: 2 years. Funding: 108 k€. Role: Responsible of Operative Unit.
Italian Ministry of Health project: “Use of stem cells in tissue engineering for the prevention of cartilage damages”. Started in March 2005. Duration: 2 years. Funding: 68 k€. Role: Responsible of Operative Unit.
Region Emilia Romagna-University Bologna project: “Regenerative medicine in osteo-articular diseases”. Started in April 2013. Duration: 3 years. Funding: 103 k€. Role: WP Principal Investigator.
2014-2018. European H2020 project: “Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis” ADIPOA2 (n. 643809). Started in January 2015. Duration: 4 years. Funding: 360 k€. Role: WP4 leader.
National project of the Ministry of Foreign Affair. Executive Programme for Scientific and Technological Cooperation Between the Italian Republic and Republic of India: “Development of 3D Bioprinted Osteochondral Tissue” Project code IN17O03. Started in January 2017. Duration: 3 years. Grant for researchers exchange. Italian Coordinator.

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Dr.ssa Elizaveta Kon

IOR

Chirurgo Ortopedico della Clinica Ortopedica e Traumatologica II e ricercatrice del Laboratorio di Biomeccanica e Innovazione Tecnologica. Responsabile dell’attività di ricerca clinica e preclinica in termini di disegno sperimentale dello studio, arruolamento dei pazienti, loro trattamento e valutazione.

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Prof. Maurilio Marcacci

Direttore della Clinica Ortopedica e Traumatologica II

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